Polysaccharide-Lipids

HAWORKS provides a specialized catalog of high-purity Polysaccharide-Lipid Conjugates engineered for targeted drug delivery systems (DDS), nanomedicine, and self-assembling biomaterials.

By covalently grafting hydrophobic lipid moieties onto hydrophilic polysaccharide backbones (such as Hyaluronic Acid, Chitosan, and Dextran), these amphiphilic biopolymers spontaneously self-assemble in aqueous media into well-defined nanostructures—including polymeric micelles, polymersomes, hybrid lipid nanoparticles (LNPs), and surface-modified liposomes.

Core Conjugate Architectures

• Hyaluronate-Lipid Conjugates (HA-Lipids):

  Amphiphilic hyaluronic acid derivatives conjugated to functional lipids (such as Cholesterol, DPPE, DSPE, or Stearic Acid). These conjugates combine intrinsic CD44 receptor targeting with stable hydrophobic cores for tumor-specific chemotherapeutic and nucleic acid delivery.

• Chitosan-Lipid Conjugates:

  Cationic, lipid-grafted chitosan engineered to enhance cellular uptake, overcome mucosal barriers, and facilitate stable encapsulation of poorly soluble small molecules and RNA/DNA therapeutics.

• Dextran & Glycan-Lipid Conjugates:

  Neutral, biocompatible conjugates designed for "stealth" nanocarrier coatings, reducing reticuloendothelial system (RES) clearance and prolonging systemic circulation.